ICSC 0209 - ACETIC ANHYDRIDE

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ACETIC ANHYDRIDE	ICSC: 0209 (November 2023)
Acetyl anhydride Acetic acid, anhydride Ethanoic anhydride Acetyl oxide

CAS #: 108-24-7

UN #: 1715

EC Number: 203-564-8

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Flammable. Many reactions may cause fire or explosion. See Chemical dangers Above 49°C explosive vapour/air mixtures may be formed.	NO contact with water or incompatible substances. See Chemical Dangers. NO open flames, NO sparks and NO smoking. Above 49°C use a closed system, ventilation and explosion-proof electrical equipment.	Use alcohol-resistant foam, powder, carbon dioxide. See Notes. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.

AVOID ALL CONTACT!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Sore throat. Cough. Burning sensation in the throat and chest. Shortness of breath. Chest pain. Laboured breathing. Symptoms may be delayed.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
Skin	Redness. Pain. Serious skin burns. Blisters.	Protective gloves. Protective clothing.	First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Wear protective gloves when administering first aid. Refer immediately for medical attention.
Eyes	Redness. Watering of the eyes. Pain. Severe burns. Corneal damage.	Wear face shield or eye protection in combination with breathing protection.	Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.
Ingestion	Burns in mouth and throat. Abdominal pain. Vomiting. Diarrhoea. Severe thirst. Shock or collapse.	Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Flammable liquid and vapour Harmful if swallowed Toxic if inhaled Causes severe skin burns and eye damage Causes damage to lungs if inhaled Transportation UN Classification UN Hazard Class: 8; UN Subsidiary Risks: 3; UN Pack Group: II
STORAGE
Store only in original container. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Fireproof. Dry.
PACKAGING
Do not transport with food and feedstuffs.

ACETIC ANHYDRIDE

ICSC: 0209

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS LIQUID WITH PUNGENT ODOUR. Physical dangers Chemical dangers Decomposes on burning. This produces carbon monoxide (see ICSC 0023) and toxic fumes including acetic acid fumes. Reacts violently with strong reducing agents, oxidants, strong bases and water. This generates fire and explosion hazard. Attacks many metals and plastics.	Formula: C₄H₆O₃/(CH₃CO)₂O Molecular mass: 102.1 Boiling point: 139°C Melting point: -73°C Relative density (water = 1): 1.08 (20°C) Solubility in water: reaction, releasing heat Vapour pressure, kPa at 20°C: 0.5 Relative vapour density (air = 1): 3.5 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01 Flash point: 49°C c.c. Auto-ignition temperature: 316°C Explosive limits, vol% in air: 2.7-10.3 Octanol/water partition coefficient as log Pow: -0.27 (calculated)

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH PUNGENT ODOUR.

Physical dangers

Chemical dangers
Decomposes on burning. This produces carbon monoxide (see ICSC 0023) and toxic fumes including acetic acid fumes. Reacts violently with strong reducing agents, oxidants, strong bases and water. This generates fire and explosion hazard. Attacks many metals and plastics.

Formula: C₄H₆O₃/(CH₃CO)₂O
Molecular mass: 102.1
Boiling point: 139°C
Melting point: -73°C
Relative density (water = 1): 1.08 (20°C)
Solubility in water: reaction, releasing heat
Vapour pressure, kPa at 20°C: 0.5
Relative vapour density (air = 1): 3.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 49°C c.c.
Auto-ignition temperature: 316°C
Explosive limits, vol% in air: 2.7-10.3
Octanol/water partition coefficient as log Pow: -0.27 (calculated)

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour and by ingestion. Effects of short-term exposure The substance is corrosive to the eyes, skin and respiratory tract. Lachrymation. Corrosive on ingestion. Inhalation may cause asthma-like reactions (RADS). Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Lachrymation. Corrosive on ingestion. Inhalation may cause asthma-like reactions (RADS). Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure

OCCUPATIONAL EXPOSURE LIMITS
MAK: 0.42 mg/m³, 0.1 ppm; peak limitation category: I(2); pregnancy risk group: C. TLV: 1 ppm as TWA; 3 ppm as STEL; A4 (not classifiable as a human carcinogen)

ENVIRONMENT
Environmental effects of the substance have been adequately investigated, but no significant effects have been found.

NOTES
Forms acetic acid when mixed with water. Major fires must be extinguished with large amounts of water from a distance.

ADDITIONAL INFORMATION

EC Classification

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