ICSC 0558 - PROPIONIC ANHYDRIDE

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PROPIONIC ANHYDRIDE	ICSC: 0558 (April 2024)
Propanoic anhydride Methylacetic anhydride Propanoic acid anhydride

CAS #: 123-62-6

UN #: 2496

EC Number: 204-638-2

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Above 63°C explosive vapour/air mixtures may be formed.	NO open flames. Above 63°C use a closed system and ventilation.	Use water spray, powder, alcohol-resistant foam, carbon dioxide.

AVOID ALL CONTACT! PREVENT GENERATION OF MISTS!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat. Burning sensation. Shortness of breath. Symptoms may be delayed. See Notes.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
Skin	Redness. Pain. Skin burns.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention .
Eyes	Redness. Pain. Severe burns.	Wear face shield or eye protection in combination with breathing protection.	Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention. Keep rinsing during transport for medical attention.
Ingestion	Burns in mouth and throat. Abdominal pain. Shock or collapse.	Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus, face shield and protective gloves. Collect leaking liquid in sealable containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Causes severe skin burns and eye damage May cause damage to lungs if inhaled May cause damage to upper respiratory tract and lungs through prolonged or repeated exposure if inhaled Transportation UN Classification UN Hazard Class: 8; UN Pack Group: III
STORAGE
Dry. Ventilation along the floor. Separated from bases, oxidants and food and feedstuffs. Store only in original container.
PACKAGING
Do not transport with food and feedstuffs.

PROPIONIC ANHYDRIDE

ICSC: 0558

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS LIQUID WITH PUNGENT ODOUR. Physical dangers The vapour is heavier than air. Chemical dangers Decomposes on contact with water. This produces corrosive propionic acid (see ICSC 0806). Reacts violently with bases and oxidants. This generates fire and explosion hazard.	Formula: C₆H₁₀O₃ / (CH₃CH₂CO)₂O Molecular mass: 130.2 Boiling point: 167°C Melting point: -45°C Relative density (water = 1): 1.01 Solubility in water: reaction Vapour pressure, kPa at 20°C: 0.1 Relative vapour density (air = 1): 4.5 Relative density of the vapour/air-mixture at 20°C (air = 1): 4.4 Flash point: 63°C c.c. Auto-ignition temperature: 285°C Explosive limits, vol% in air: 1.3-9.5

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH PUNGENT ODOUR.

Physical dangers
The vapour is heavier than air.

Chemical dangers
Decomposes on contact with water. This produces corrosive propionic acid (see ICSC 0806). Reacts violently with bases and oxidants. This generates fire and explosion hazard.

Formula: C₆H₁₀O₃ / (CH₃CH₂CO)₂O
Molecular mass: 130.2
Boiling point: 167°C
Melting point: -45°C
Relative density (water = 1): 1.01
Solubility in water: reaction
Vapour pressure, kPa at 20°C: 0.1
Relative vapour density (air = 1): 4.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 4.4
Flash point: 63°C c.c.
Auto-ignition temperature: 285°C
Explosive limits, vol% in air: 1.3-9.5

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation and by ingestion. Effects of short-term exposure The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. See Notes.	Inhalation risk No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. Effects of long-term or repeated exposure Repeated or chronic inhalation of the vapour may cause chronic inflammation of the upper respiratory tract. The substance may have effects on the lungs. This may result in bronchitis.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. See Notes.

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.

Effects of long-term or repeated exposure
Repeated or chronic inhalation of the vapour may cause chronic inflammation of the upper respiratory tract. The substance may have effects on the lungs. This may result in bronchitis.

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT

NOTES
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor, or by an authorized person, should be considered.

ADDITIONAL INFORMATION

EC Classification

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