ICSC 0499 - ISOPHORONE DIISOCYANATE

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ISOPHORONE DIISOCYANATE	ICSC: 0499 (November 2008)
3-Isocyanatomethyl - 3,5,5-trimethylcyclohexyl isocyanate Isocyanic acid, methylene (3,5,5-trimethyl-3, 1-cyclohexylene)ester IPDI

CAS #: 4098-71-9

UN #: 2290

EC Number: 223-861-6

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.	NO open flames.	Use water spray, foam, powder, carbon dioxide.

AVOID ALL CONTACT!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat. Burning sensation.	Use closed system.	Fresh air, rest. Half-upright position. Refer immediately for medical attention.
Skin	Redness. Pain. Serious skin burns.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes	Redness. Pain.	Wear face shield or eye protection in combination with breathing protection.	Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Ingestion	Sore throat. Burning sensation. Abdominal pain.	Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Treat remaining liquid with a mixture of ammonia (4-8%), detergent (2%), and water. Do NOT let this chemical enter the environment.	According to UN GHS Criteria Fatal if inhaled Harmful in contact with skin Causes severe skin burns and eye damage May cause allergic or asthmatic symptoms or breathing difficulties if inhaled May cause allergic skin reaction Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: III
STORAGE
Separated from bases, acids, alcohols, amines, amides, phenols, mercaptans and food and feedstuffs. Keep in a well-ventilated room. Well closed. Cool. Dry. Store in an area without drain or sewer access.
PACKAGING
Airtight. Do not transport with food and feedstuffs.

ISOPHORONE DIISOCYANATE

ICSC: 0499

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS-TO-YELLOW LIQUID WITH PUNGENT ODOUR. Physical dangers Chemical dangers The substance may polymerize. Decomposes on burning. This produces toxic and corrosive fumes including hydrogen cyanide and nitrogen oxides. Reacts with acids, alcohol, amines, bases, amides, phenols and mercaptans. This generates toxic, fire and explosion hazard. Attacks plastics and rubber.	Formula: C₁₂H₁₈N₂O₂ / (CH₃)₂C₆H₇(CH₃)(N=C=O)CH₂N=C=O Molecular mass: 222.3 Boiling point at 1.33kPa: 158°C Decomposes at 310°C Melting point: -60°C Relative density (water = 1): 1.06 Solubility in water, g/100ml: 15 (reaction) Vapour pressure, Pa at 20°C: 0.04 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0 Flash point: 155°C c.c. Auto-ignition temperature: 430°C Explosive limits, vol% in air: 0.7-4.5 Octanol/water partition coefficient as log Pow: 4.75 (calculated)

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-YELLOW LIQUID WITH PUNGENT ODOUR.

Physical dangers

Chemical dangers
The substance may polymerize. Decomposes on burning. This produces toxic and corrosive fumes including hydrogen cyanide and nitrogen oxides. Reacts with acids, alcohol, amines, bases, amides, phenols and mercaptans. This generates toxic, fire and explosion hazard. Attacks plastics and rubber.

Formula: C₁₂H₁₈N₂O₂ / (CH₃)₂C₆H₇(CH₃)(N=C=O)CH₂N=C=O
Molecular mass: 222.3
Boiling point at 1.33kPa: 158°C
Decomposes at 310°C
Melting point: -60°C
Relative density (water = 1): 1.06
Solubility in water, g/100ml: 15 (reaction)
Vapour pressure, Pa at 20°C: 0.04
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 155°C c.c.
Auto-ignition temperature: 430°C
Explosive limits, vol% in air: 0.7-4.5
Octanol/water partition coefficient as log Pow: 4.75 (calculated)

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol and through the skin. Effects of short-term exposure The substance is corrosive to the skin. The substance is severely irritating to the eyes. The aerosol is irritating to the respiratory tract.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying. Effects of long-term or repeated exposure Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and through the skin.

Effects of short-term exposure
The substance is corrosive to the skin. The substance is severely irritating to the eyes. The aerosol is irritating to the respiratory tract.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying.

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.005 ppm as TWA. MAK: 0.046 mg/m³, 0.005 ppm; peak limitation category: I(1); sensitization of respiratory tract and skin (SAH); pregnancy risk group: D

ENVIRONMENT
This substance may be hazardous to the environment. Special attention should be given to aquatic organisms.

NOTES
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact. The odour warning when the exposure limit value is exceeded is insufficient. Do NOT take working clothes home.

ADDITIONAL INFORMATION

EC Classification
Symbol: T, N; R: 23-36/37/38-42/43-51/53; S: (1/2)-26-28-38-45-61; Note: 2

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