ICSC 0457 - N,N-DIMETHYLFORMAMIDE

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N,N-DIMETHYLFORMAMIDE	ICSC: 0457 (April 2014)
Dimethylformamide DMF DMFA N-Formyldimethylamine

CAS #: 68-12-2

UN #: 2265

EC Number: 200-679-5

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 58°C explosive vapour/air mixtures may be formed.	NO open flames, NO sparks and NO smoking. NO contact with oxidizing agents. Above 58°C use a closed system and ventilation.	Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Sore throat. Abdominal pain. Diarrhoea. Vomiting. Symptoms may be delayed. See Notes.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Refer for medical attention.
Skin	MAY BE ABSORBED! See Inhalation.	Barrier cream. Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes	Redness. Pain.	Wear safety goggles or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Aspiration hazard! Abdominal pain. Jaundice.	Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria Flammable liquid and vapour May be harmful if swallowed or in contact with skin Harmful if inhaled Causes serious eye irritation May damage fertility or the unborn child May cause damage to liver May be harmful if swallowed and enters airways Transportation UN Classification UN Hazard Class: 3; UN Pack Group: III
STORAGE
Separated from incompatible materials. See Chemical Dangers.
PACKAGING

N,N-DIMETHYLFORMAMIDE

ICSC: 0457

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS-TO-YELLOW LIQUID WITH CHARACTERISTIC ODOUR. Physical dangers Chemical dangers Decomposes on heating. This produces toxic fumes including nitrogen oxides. Reacts violently with strong oxidants, halogens, halogenated hydrocarbons and nitrates. Attacks some plastics and rubber.	Formula: C₃H₇NO / HCON(CH₃)₂ Molecular mass: 73.1 Boiling point: 153°C Melting point: -61°C Relative density (water = 1): 0.95 Solubility in water: miscible Vapour pressure, kPa at 25°C: 0.49 Relative vapour density (air = 1): 2.5 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 58°C c.c. Auto-ignition temperature: 440°C Octanol/water partition coefficient as log Pow: -0.87 Viscosity: 0.85 mm²/s at 25°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-YELLOW LIQUID WITH CHARACTERISTIC ODOUR.

Physical dangers

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides. Reacts violently with strong oxidants, halogens, halogenated hydrocarbons and nitrates. Attacks some plastics and rubber.

Formula: C₃H₇NO / HCON(CH₃)₂
Molecular mass: 73.1
Boiling point: 153°C
Melting point: -61°C
Relative density (water = 1): 0.95
Solubility in water: miscible
Vapour pressure, kPa at 25°C: 0.49
Relative vapour density (air = 1): 2.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 58°C c.c.
Auto-ignition temperature: 440°C
Octanol/water partition coefficient as log Pow: -0.87
Viscosity: 0.85 mm²/s at 25°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation and through the skin. Effects of short-term exposure The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the liver. This may result in tissue lesions. The effects may be delayed. Medical observation is indicated. See Notes. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis.	Inhalation risk A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure The substance may have effects on the liver. This may result in impaired functions. Tumours have been detected in experimental animals but may not be relevant to humans. Animal tests show that this substance possibly causes toxic effects upon human reproduction.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin.

Effects of short-term exposure
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the liver. This may result in tissue lesions. The effects may be delayed. Medical observation is indicated. See Notes. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis.

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
The substance may have effects on the liver. This may result in impaired functions. Tumours have been detected in experimental animals but may not be relevant to humans. Animal tests show that this substance possibly causes toxic effects upon human reproduction.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 5 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued. MAK: 15 mg/m³, 5 ppm; peak limitation category: II(2); skin absorption (H); carcinogen category: 4; pregnancy risk group: B. EU-OEL: 15 mg/m³, 5 ppm as TWA; 30 mg/m³, 10 ppm as STEL; (skin)

ENVIRONMENT
Environmental effects of the substance have been adequately investigated, but no significant effects have been found.

NOTES
The symptoms of poisoning do not become manifest until a few hours or even days have passed. Use of alcoholic beverages enhances the harmful effect.

ADDITIONAL INFORMATION

EC Classification
Symbol: T; R: 61-20/21-36; S: 53-45; Note: E

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