ICSC 0339 - 2,4-TOLUENE DIISOCYANATE

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2,4-TOLUENE DIISOCYANATE	ICSC: 0339 (May 2018)
2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene

CAS #: 584-84-9

UN #: 2078

EC Number: 209-544-5

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion as a result of decomposition when heated.	NO open flames. NO contact with water.	Use powder, carbon dioxide, water in large amounts. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Sore throat. Cough. Headache. Nausea. Vomiting. Shortness of breath. Laboured breathing. Symptoms may be delayed. See Notes.	Use local exhaust. Use breathing protection.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
Skin	Redness. Blisters. Pain.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes	Redness. Pain. Blurred vision.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	See Inhalation.	Do not eat, drink, or smoke during work.	Rinse mouth. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Special emergency response required.	According to UN GHS Criteria DANGER Fatal if inhaled Causes skin irritation Causes serious eye irritation May cause respiratory irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction Suspected of causing cancer Harmful to aquatic life with long lasting effects Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from food and feedstuffs. Separated from : see Chemical Dangers. Store between 20°C and 25°C. Dry. Keep in a well-ventilated room. Store in an area without drain or sewer access. Refer to the manufacturer's instructions for proper storage conditions.
PACKAGING
Do not transport with food and feedstuffs.

2,4-TOLUENE DIISOCYANATE

ICSC: 0339

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS-TO-PALE YELLOW LIQUID OR CRYSTALS WITH PUNGENT ODOUR. TURNS PALE YELLOW ON EXPOSURE TO AIR. Physical dangers Chemical dangers The substance polymerizes with water and many chemicals in a hazardous way. This generates fire or explosion hazard. On combustion, forms toxic gases. This generates toxic hazard.	Formula: C₉H₆N₂O₂ / CH₃C₆H₃(NCO)₂ Molecular mass: 174.2 Boiling point: 251°C Melting point: 22°C Relative density (water = 1): 1.2 Solubility in water: reaction Vapour pressure, Pa at 20°C: 1.3 Relative vapour density (air = 1): 6.0 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 127°C c.c. Auto-ignition temperature: 620°C Explosive limits, vol% in air: 0.9-9.5 Octanol/water partition coefficient as log Pow: 3.4

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-PALE YELLOW LIQUID OR CRYSTALS WITH PUNGENT ODOUR. TURNS PALE YELLOW ON EXPOSURE TO AIR.

Physical dangers

Chemical dangers
The substance polymerizes with water and many chemicals in a hazardous way. This generates fire or explosion hazard. On combustion, forms toxic gases. This generates toxic hazard.

Formula: C₉H₆N₂O₂ / CH₃C₆H₃(NCO)₂
Molecular mass: 174.2
Boiling point: 251°C
Melting point: 22°C
Relative density (water = 1): 1.2
Solubility in water: reaction
Vapour pressure, Pa at 20°C: 1.3
Relative vapour density (air = 1): 6.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 127°C c.c.
Auto-ignition temperature: 620°C
Explosive limits, vol% in air: 0.9-9.5
Octanol/water partition coefficient as log Pow: 3.4

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol and by ingestion. Effects of short-term exposure The substance, the vapour of this substance and the aerosol are irritating to the eyes, skin and respiratory tract. Inhalation of the vapour may cause asthma-like reactions. Inhalation of the vapour may cause chemical bronchitis, pneumonitis and lung oedema. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol and by ingestion.

Effects of short-term exposure
The substance, the vapour of this substance and the aerosol are irritating to the eyes, skin and respiratory tract. Inhalation of the vapour may cause asthma-like reactions. Inhalation of the vapour may cause chemical bronchitis, pneumonitis and lung oedema. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans.

OCCUPATIONAL EXPOSURE LIMITS
TLV: (inhalable fraction and vapour): 0.001 ppm as TWA; 0.005 ppm as STEL; (skin); (DSEN); (RSEN); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued. MAK: (vapour and aerosol): 0.007 mg/m³, 0.001 ppm; peak limitation category: I(1); (momentary value that should not be exceeded): 0.035 mg/m³, 0.005 ppm; pregnancy risk group: C; sensitization of respiratory tract and skin (SAH)

OCCUPATIONAL EXPOSURE LIMITS

TLV: (inhalable fraction and vapour): 0.001 ppm as TWA; 0.005 ppm as STEL; (skin); (DSEN); (RSEN); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued.
MAK: (vapour and aerosol): 0.007 mg/m³, 0.001 ppm; peak limitation category: I(1); (momentary value that should not be exceeded): 0.035 mg/m³, 0.005 ppm; pregnancy risk group: C; sensitization of respiratory tract and skin (SAH)

ENVIRONMENT
The substance is harmful to aquatic organisms. The substance may cause long-term effects in the aquatic environment.

NOTES
Technical toluene diisocyanate is either 100% 2,4- or a mixture of 2,4- and 2,6-isomers. TDI is a common name. CAS number of the mixture is 26471-62-5. Depending on the degree of exposure, periodic medical examination is suggested. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Anyone who has shown symptoms of asthma due to this substance should avoid all further contact. The odour warning when the exposure limit value is exceeded is insufficient.

NOTES

Technical toluene diisocyanate is either 100% 2,4- or a mixture of 2,4- and 2,6-isomers. TDI is a common name. CAS number of the mixture is 26471-62-5.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The odour warning when the exposure limit value is exceeded is insufficient.

ADDITIONAL INFORMATION

EC Classification
Symbol: T+; R: 26-36/37/38-40-42/43-52/53; S: (1/2)-23-36/37-45-61; Note: C

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