ICSC 0320 - PROPIONITRILE

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PROPIONITRILE	ICSC: 0320 (June 2011)
Propanenitrile Ethyl cyanide Cyanoethane

CAS #: 107-12-0

UN #: 2404

EC Number: 203-464-4

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting. Vapour/air mixtures are explosive. Heating will cause rise in pressure with risk of bursting. Risk of fire and explosion on contact with strong oxidants.	NO open flames, NO sparks and NO smoking. NO contact with hot surfaces or strong oxidizing agents. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.	Use powder, foam, carbon dioxide. Water may be ineffective. In case of fire: keep drums, etc., cool by spraying with water.

STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Headache. Sore throat. Chest tightness. Shortness of breath. Nausea. Vomiting. Lethargy. Unconsciousness. Respiratory and cardiac arrest. Symptoms may be delayed.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention. See Notes.
Skin	EASILY ABSORBED! Redness.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.
Eyes	Redness. Pain.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	See Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Consult an expert! Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria Highly flammable liquid and vapour Fatal if swallowed, in contact with skin or if inhaled May cause drowsiness or dizziness Causes skin and eye irritation May cause respiratory irritation May be harmful if swallowed and enters airways Transportation UN Classification UN Hazard Class: 3; UN Subsidiary Risks: 6.1; UN Pack Group: II
STORAGE
Fireproof. Keep in a well-ventilated room. Separated from strong oxidants, acids and food and feedstuffs.
PACKAGING
Do not transport with food and feedstuffs.

PROPIONITRILE

ICSC: 0320

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Physical dangers The vapour mixes well with air, explosive mixtures are easily formed. The vapour is heavier than air and may travel along the ground; distant ignition possible. Chemical dangers Decomposes on heating or on burning and on contact with hot surfaces. This produces toxic fumes including nitrogen oxides and hydrogen cyanide. Reacts violently with strong oxidants. This generates fire and explosion hazard. Reacts with acids, steam and warm water. This produces toxic and flammable hydrogen cyanide.	Formula: C₃H₅N / CH₃CH₂CN Molecular mass: 55.1 Boiling point: 97°C Melting point: -92°C Relative density (water = 1): 0.78 Solubility in water, g/100ml at 20°C: 10 (good) Vapour pressure, kPa at 20°C: 5.2 Relative vapour density (air = 1): 1.9 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05 Flash point: 2°C c.c. Explosive limits, vol% in air: 3.1-? Octanol/water partition coefficient as log Pow: 0.16 Auto-ignition temperature: 510°C Viscosity: 0,44 mPa*s at 20°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Physical dangers
The vapour mixes well with air, explosive mixtures are easily formed. The vapour is heavier than air and may travel along the ground; distant ignition possible.

Chemical dangers
Decomposes on heating or on burning and on contact with hot surfaces. This produces toxic fumes including nitrogen oxides and hydrogen cyanide. Reacts violently with strong oxidants. This generates fire and explosion hazard. Reacts with acids, steam and warm water. This produces toxic and flammable hydrogen cyanide.

Formula: C₃H₅N / CH₃CH₂CN
Molecular mass: 55.1
Boiling point: 97°C
Melting point: -92°C
Relative density (water = 1): 0.78
Solubility in water, g/100ml at 20°C: 10 (good)
Vapour pressure, kPa at 20°C: 5.2
Relative vapour density (air = 1): 1.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05
Flash point: 2°C c.c.
Explosive limits, vol% in air: 3.1-?
Octanol/water partition coefficient as log Pow: 0.16
Auto-ignition temperature: 510°C
Viscosity: 0,44 mPa*s at 20°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Effects of short-term exposure The substance is moderately irritating to the eyes and skin. The vapour is irritating to the upper respiratory tract. The substance may cause effects on the cellular respiration. This may result in metabolic acidosis, central nervous system depression, cardiac disorders and death. Medical observation is indicated.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure The substance may have effects on the blood. This may result in anaemia. Ingestion may cause effects on the gastrointestinal tract. This may result in ulceration. The substance may have effects on the kidneys, liver and thyroid. This may result in impaired functions.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Effects of short-term exposure
The substance is moderately irritating to the eyes and skin. The vapour is irritating to the upper respiratory tract. The substance may cause effects on the cellular respiration. This may result in metabolic acidosis, central nervous system depression, cardiac disorders and death. Medical observation is indicated.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in anaemia. Ingestion may cause effects on the gastrointestinal tract. This may result in ulceration. The substance may have effects on the kidneys, liver and thyroid. This may result in impaired functions.

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT
This substance may be hazardous to the environment. Special attention should be given to aquatic organisms.

NOTES
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Oxygen should be administered exclusively by specially trained first aid or medical personnel. Do NOT take working clothes home. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. See ICSCs 0088, 0492, 0671 and 1118.

NOTES

Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Oxygen should be administered exclusively by specially trained first aid or medical personnel.
Do NOT take working clothes home.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
See ICSCs 0088, 0492, 0671 and 1118.

ADDITIONAL INFORMATION

EC Classification

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