ICSC 0259 - N,N-DIMETHYLACETAMIDE

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N,N-DIMETHYLACETAMIDE	ICSC: 0259 (October 2006)
DMAC Acetic acid dimethylamide Dimethylacetamide

CAS #: 127-19-5

EC Number: 204-826-4

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 63°C explosive vapour/air mixtures may be formed.	NO open flames. Above 63°C use a closed system, ventilation and explosion-proof electrical equipment.	Use powder, alcohol-resistant foam, water spray, carbon dioxide.

STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Headache. Nausea.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Refer for medical attention.
Skin	MAY BE ABSORBED! Redness. Further see Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes		Wear face shield.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal cramps. Diarrhoea. Further see Inhalation.	Do not eat, drink, or smoke during work.	Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Seek medical attention if you feel unwell.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: chemical protection suit. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Causes damage to the liver through prolonged or repeated exposure if in contact with skin Transportation UN Classification
STORAGE
Ventilation along the floor. Separated from strong oxidants.
PACKAGING

N,N-DIMETHYLACETAMIDE

ICSC: 0259

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance OILY COLOURLESS LIQUID WITH PUNGENT ODOUR. Physical dangers Chemical dangers Decomposes on heating. This produces toxic fumes. Reacts with strong oxidants.	Formula: C₄H₉NO / CH₃CON(CH₃)₂ Molecular mass: 87.1 Boiling point: 165°C Melting point: -20°C Relative density (water = 1): 0.94 Solubility in water: miscible Vapour pressure, kPa at 20°C: 0.33 Relative vapour density (air = 1): 3.01 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01 Flash point: 63°C c.c. Auto-ignition temperature: 490°C Explosive limits, vol% in air: 1.8 - 11.5 Octanol/water partition coefficient as log Pow: -0.77

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
OILY COLOURLESS LIQUID WITH PUNGENT ODOUR.

Physical dangers

Chemical dangers
Decomposes on heating. This produces toxic fumes. Reacts with strong oxidants.

Formula: C₄H₉NO / CH₃CON(CH₃)₂
Molecular mass: 87.1
Boiling point: 165°C
Melting point: -20°C
Relative density (water = 1): 0.94
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 0.33
Relative vapour density (air = 1): 3.01
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 63°C c.c.
Auto-ignition temperature: 490°C
Explosive limits, vol% in air: 1.8 - 11.5
Octanol/water partition coefficient as log Pow: -0.77

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation and through the skin. Effects of short-term exposure	Inhalation risk A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure The substance may have effects on the liver. This may result in impaired functions. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin.

Effects of short-term exposure

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
The substance may have effects on the liver. This may result in impaired functions. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 10 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued. MAK: 18 mg/m³, 5 ppm; peak limitation category: II(2); skin absorption (H); pregnancy risk group: C. EU-OEL: 36 mg/m³, 10 ppm as TWA; 72 mg/m³, 20 ppm as STEL; (skin)

ENVIRONMENT

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. There is no odour warning even when toxic concentrations are present.

ADDITIONAL INFORMATION

EC Classification
Note: E; Symbol: T; R: 61-20/21; S: 53-45

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