ICSC 0148 - DIMETHYL SULFATE

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DIMETHYL SULFATE	ICSC: 0148 (November 2008)
Sulfuric acid dimethyl ester Dimethyl monosulfate DMS

CAS #: 77-78-1

UN #: 1595

EC Number: 201-058-1

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 83°C explosive vapour/air mixtures may be formed.	NO open flames. Above 83°C use a closed system and ventilation.	Use powder, foam, carbon dioxide, water spray.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat. Burning sensation. Shortness of breath. Headache. Symptoms may be delayed. See Notes.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
Skin	MAY BE ABSORBED! Redness. Pain. Blisters. Skin burns.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.
Eyes	Redness. Pain. Burns. Permanent loss of vision.	Wear face shield or eye protection in combination with breathing protection.	Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Ingestion	Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal cramps. Vomiting. Convulsions. Shock or collapse. Further see Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Combustible liquid Fatal if inhaled Toxic if swallowed Causes severe skin burns and eye damage May cause allergic skin reaction Suspected of causing genetic defects May cause cancer Causes damage to liver, kidneys and lungs Causes damage to the lungs through prolonged or repeated exposure Harmful to aquatic life Transportation UN Classification UN Hazard Class: 6.1; UN Subsidiary Risks: 8; UN Pack Group: I
STORAGE
Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Cool. Dry. Well closed. Ventilation along the floor. Store in an area without drain or sewer access.
PACKAGING
Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.

DIMETHYL SULFATE

ICSC: 0148

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS OILY LIQUID. Physical dangers Chemical dangers Decomposes on heating and on burning. This produces toxic fumes including sulfur oxides. The solution is a medium strong acid. Reacts with water. This produces sulfuric acid. This generates heat. Reacts violently with concentrated aqueous ammonia, bases, acids and strong oxidants. This generates fire and explosion hazard.	Formula: C₂H₆O₄S / (CH₃O)₂SO₂ Molecular mass: 126.1 Decomposes at 188°C Melting point: -32°C Relative density (water = 1): 1.3 Solubility in water, g/100ml at 18°C: 2.8 Vapour pressure, Pa at 20°C: 65 Relative vapour density (air = 1): 4.4 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 83°C c.c. Auto-ignition temperature: 470°C Explosive limits, vol% in air: 3.6-23.3 Octanol/water partition coefficient as log Pow: 0.16

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS OILY LIQUID.

Physical dangers

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including sulfur oxides. The solution is a medium strong acid. Reacts with water. This produces sulfuric acid. This generates heat. Reacts violently with concentrated aqueous ammonia, bases, acids and strong oxidants. This generates fire and explosion hazard.

Formula: C₂H₆O₄S / (CH₃O)₂SO₂
Molecular mass: 126.1
Decomposes at 188°C
Melting point: -32°C
Relative density (water = 1): 1.3
Solubility in water, g/100ml at 18°C: 2.8
Vapour pressure, Pa at 20°C: 65
Relative vapour density (air = 1): 4.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 83°C c.c.
Auto-ignition temperature: 470°C
Explosive limits, vol% in air: 3.6-23.3
Octanol/water partition coefficient as log Pow: 0.16

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Effects of short-term exposure The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. See Notes. The substance may cause effects on the liver and kidneys. This may result in impaired functions. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.	Inhalation risk A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure Repeated or prolonged inhalation of the vapour may cause effects on the lungs. This substance is probably carcinogenic to humans. Repeated or prolonged contact may cause skin sensitization.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. See Notes. The substance may cause effects on the liver and kidneys. This may result in impaired functions. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
Repeated or prolonged inhalation of the vapour may cause effects on the lungs. This substance is probably carcinogenic to humans. Repeated or prolonged contact may cause skin sensitization.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.1 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans). MAK: skin absorption (H); carcinogen category: 2

ENVIRONMENT
The substance is harmful to aquatic organisms.

NOTES
Commercial dimethyl sulfate may contain trace amounts of sulfuric acid. Depending on the degree of exposure, periodic medical examination is suggested. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor, or by an authorized person, should be considered. There is no odour warning even when toxic concentrations are present. Do NOT take working clothes home.

NOTES

Commercial dimethyl sulfate may contain trace amounts of sulfuric acid.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Immediate administration of an appropriate inhalation therapy by a doctor, or by an authorized person, should be considered.
There is no odour warning even when toxic concentrations are present.
Do NOT take working clothes home.

ADDITIONAL INFORMATION

EC Classification
Symbol: T+; R: 45-25-26-34-43-68; S: 53-45; Note: E

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