ICSC 0026 - 4-CHLOROANILINE

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4-CHLOROANILINE	ICSC: 0026 (October 2001)
Chloroaminobenzene, p- Chloroaniline, p-

CAS #: 106-47-8

UN #: 2018

EC Number: 203-401-0

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, powder, foam, carbon dioxide.

PREVENT DISPERSION OF DUST! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Blue lips, fingernails and skin. Confusion. Convulsions. Dizziness. Headache. Nausea. Unconsciousness.	Use local exhaust or breathing protection.	Fresh air, rest. Refer for medical attention.
Skin	MAY BE ABSORBED! Further see Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes	Redness. Pain.	Wear safety goggles or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	See Inhalation.	Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: P3 filter respirator for toxic particles and chemical protection suit. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from strong oxidants and food and feedstuffs.
PACKAGING
Do not transport with food and feedstuffs.

4-CHLOROANILINE

ICSC: 0026

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS-TO-YELLOW CRYSTALS WITH CHARACTERISTIC ODOUR. Physical dangers Chemical dangers Decomposes on burning. This produces toxic and corrosive fumes including hydrogen chloride and nitrogen oxides. Reacts violently with oxidants.	Formula: C₆H₆ClN / ClC₆H₄NH₂ Molecular mass: 127.6 Boiling point: 232°C Melting point: 69-72.5°C Relative density (water = 1): 1.4 Solubility in water, g/100ml at 20°C: 0.39 Vapour pressure, Pa at 20°C: 2 Relative vapour density (air = 1): 4.4 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 120-123°C o.c. Auto-ignition temperature: 685°C Octanol/water partition coefficient as log Pow: 1.8

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-YELLOW CRYSTALS WITH CHARACTERISTIC ODOUR.

Physical dangers

Chemical dangers
Decomposes on burning. This produces toxic and corrosive fumes including hydrogen chloride and nitrogen oxides. Reacts violently with oxidants.

Formula: C₆H₆ClN / ClC₆H₄NH₂
Molecular mass: 127.6
Boiling point: 232°C
Melting point: 69-72.5°C
Relative density (water = 1): 1.4
Solubility in water, g/100ml at 20°C: 0.39
Vapour pressure, Pa at 20°C: 2
Relative vapour density (air = 1): 4.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 120-123°C o.c.
Auto-ignition temperature: 685°C
Octanol/water partition coefficient as log Pow: 1.8

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Effects of short-term exposure The substance is irritating to the eyes. The substance may cause effects on the red blood cells. This may result in lesions of blood cells and the formation of methaemoglobin. Medical observation is indicated. The effects may be delayed.	Inhalation risk A harmful concentration of airborne particles can be reached quickly when dispersed. Effects of long-term or repeated exposure Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the spleen. Tumours have been detected in experimental animals but may not be relevant to humans. See Notes.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Effects of short-term exposure
The substance is irritating to the eyes. The substance may cause effects on the red blood cells. This may result in lesions of blood cells and the formation of methaemoglobin. Medical observation is indicated. The effects may be delayed.

Inhalation risk
A harmful concentration of airborne particles can be reached quickly when dispersed.

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the spleen. Tumours have been detected in experimental animals but may not be relevant to humans. See Notes.

OCCUPATIONAL EXPOSURE LIMITS
MAK: skin absorption (H); sensitization of skin (SH); carcinogen category: 2

ENVIRONMENT
The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.

ADDITIONAL INFORMATION

EC Classification
Symbol: T, N; R: 45-23/24/25-43-50/53; S: 53-45-60-61; Note: E

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